Asthma Education Series: Asthma mythbusting

Okay, so. As part of my asthma education series, I’m gonna drop a bit of asthma mythbusting on you. Here’s 9 myths and one actual fact. The statement that’s actually true might surprise you. If you have more myths you’d like fact checked, drop them in the comments – I’m perfectly happy to post a sequel post.

  1. Most kids with asthma outgrow asthma: FALSE. While some do outgrow asthma, latest evidence suggests that up to half of those who initially seem to outgrow it relapse later in life (often in middle age). As well, kids with more severe asthma are less likely to even get a remission. In all, only about 20% of asthmatic kids will outgrow asthma entirely.
  2. If someone is having an asthma attack, you should move them somewhere cold: FALSE. While some first aid information for asthma says to move someone to clear air if there’s an airborne trigger (smoke, etc), cold air is actually an asthma trigger and is likely to make the flareup worse.
  3. Asthmatics don’t need their inhalers, what they need is willpower: FALSE. Asthma is a physiological condition with measurable obstruction to airways. You cannot will yourself past being unable to breathe.
  4. Kids who always get asthma attacks in gym class are just being lazy. FALSE. Exercise is an asthma trigger in 50% of cases. Flare-ups in response to exercise are thus a sign of inadequate asthma control, not of laziness.
  5. “When I was a kid, there didn’t seem to be as much asthma.” ACTUALLY TRUE. Asthma rates are increasing. They have been increasing since at least the 1950s, especially in the developed world, even controlling for improvements in screening and diagnosis. There didn’t seem to be as much asthma when you were a kid because there actually wasn’t. That said, increase in asthma rates nowadays does not mean that those who have asthma now are somehow faking or invalid in their diagnosis, it’s simply more common now than 30, 40, or 50 years ago.
  6. If you use your medicine “too much,” you’ll build a tolerance to it and then it won’t work. FALSE. Asthma medicines are not addictive and the body does not build a tolerance to them. What can happen, however, is that a person can use their rescue (reliever) medication to cover up a worsening of their overall asthma without actually treating the underlying cause of the symptoms (inflammation) which is just getting worse and worse. Eventually, this can lead to a very serious asthma attack that medicine doesn’t work for. This is why it’s important to apply your asthma action plan and talk with your doctor if you’re having more flare-ups and symptoms than normal.
  7. If you have asthma, you can’t do well in sports. FALSE. 20% of the Canadian Olympic Team has asthma.
  8. Kids/people with asthma shouldn’t exercise. FALSE. Exercise is associated with improved asthma control.
  9. Steroids used to treat asthma will make me bulk up. FALSE. You’re thinking anabolic steroids, which are the type used by athletes in doping scandals. The steroids used to treat asthma are corticosteroids, which work in a very different manner on a very different set of pathways. Additionally, most cases of asthma are treated with very low doses of inhaled steroids, which substantially lowers the risk of side-effects.
  10. An asthmatic complaining about my perfume/smoking/cleaning products is just being dramatic. FALSE. Many asthmatics are triggered by airborne irritants, including perfumes, cigarette smoke, and cleaning products. This induces asthma symptoms that may range from merely unpleasant (chest pain and coughing) to serious and potentially life threatening (severe difficulty breathing). An asthmatic who complains to you about your scented product is not being dramatic, they’re suffering. Be considerate of their condition and stop exposing them to a trigger. Reactions to triggers can sometimes be delayed, so even if someone doesn’t look like they’re suffering now, that doesn’t mean that they won’t be up all night coughing.

The previous post in this series is here.
The next post in this series is here.

Astham Education Series: Asthma equipment. Part 1: Med delivery systems

As I hinted in my last post in the series, this is going to be a post about all the different gadgets an asthmatic might have. The post will include links and descriptions, but as I have none of the rights to images, I won’t be using them directly here. Instead I’ll link to an article or image of one somewhere else and direct traffic to the person who created the image.

There are a few major categories that I’ll separate everything into just to keep stuff organized and a bit easier to follow: There are medication delivery systems – nebulizers, spacers, metered dose inhalers, dry powder inhalers, and the like. There are at home testing supplies – peak flow meter, pulmonary function testers, and pulse oximeters. There are accessories – specialized ways of carrying around your meds and equipment. Lastly, there are bookkeeping tools for keeping a symptom log – I’ll explore both hardcopy and software options.

This post, for the purpose of length, is going to be split into 3 parts: Medication delivery systems, at-home testing supplies, and accessories and bookkeeping supplies. This is the first part: Medication delivery systems.

What I call a medication delivery system is just a tool that lets you get your meds where they need to be. For people with injected drugs, this would be needles and syringes and suchlike. For asthmatics, they tend to be things that help you inhale stuff into your lungs (although some asthmatics, mostly extremely severe asthmatics, do use auto-injectors and injection pumps, so I’ll include those in this post, too).

The most recognizable medication delivery system is the metered dose inhaler (MDI). MDIs are a way of turning asthma medicine into a mist of fine particles small enough to get into your lungs. A good description of how they work can be found here. In short, the canister contains a mixture of propellant (a liquified, nontoxic and chemically inert gas), medicine, and one or more stabilizers.* The canister is connected to a valve which can only dispense a certain amount of the mixture at a time. When you squeeze the inhaler, the valve is opened briefly and the propellant expands rapidly, forcing the medicine out and into the air as a fine mist, which is then inhaled. Taking an MDI is a bit of an exercise in coordination. Instructions on how to use them properly are provided in detail by reliable medical websites such as Medline, or you can speak with a doctor, nurse, nurse practitioner, respiratory therapist, or pharmacist, all of whom should be able to instruct you in proper inhaler technique. In short, take the cap off, shake the inhaler, hold it about the width of two fingers in front of your mouth, breathe out gently and completely, then squeeze the canister down into the plastic holder as you inhale. Then hold your breath for 10 seconds, and breathe out slowly. It will take some practice to get the hang of the hand-lung coordination.

If you have trouble with taking an MDI properly, or if you are prone to severe attacks, you and your doctor may decide it’s a good idea to add a valved holding chamber or spacer. These are long, hollow, antistatic bubbles or tubes designed to eliminate the hand-lung coordination aspect of MDI use. How to use a spacer varies slightly depending on the design and brand, but typically you insert the MDI into one end, and either put the mask over the face of the person using it (if it has a mask) or put your mouth around the mouthpiece, then the medication is taken as directed by the spacer manufacturer. Spacers tend to be bulky and obvious, so it will usually attract attention and questions if you have or use one.

Let’s say you need a medicine that doesn’t come in a metered dose inhaler, or that you can’t do the breathing necessary to use one, even with a spacer. This is where nebulizers come in. Nebulizers are machines designed to make a mist of your medicine, which you then inhale. Because they tend not to be airtight, they’re not nearly as efficient with the medicine as MDIs or spacers, and as a result, you will have to use more medicine for the same effect. Like with spacers, proper nebulizer use varies a bit from device to device, but if you have one, you can speak to your pharmacist about how to use it. They are fairly straightforward once you know how to set them up, but they’re noisy and time-consuming relative to inhalers.

Next up is dry powder inhalers (DPIs). DPIs are a good alternative for those who don’t like noise or those who find they’re sensitive to propellants or stabilizers (of which I am one – certain brands of rescue puffer have a stabilizer that results in my asthma attack getting worse, not better, so I have to be careful which rescue inhalers I buy). DPIs do not have stabilizers or propellants. Instead they’re use dry, finely ground powder compounded with a bulking agent (usually lactose) contained in a capsule. Using the DPI properly pierces the capsule, and then you inhaling medicine from the inhaler carries it into your lungs. For DPIs to be appropriate for you, you need to be able to make a certain minimum inhalation force because otherwise the powder won’t get carried into your lungs, and so your doctor will usually give you a practice unit which will make noise when you inhale properly. If you’re unable to inhale strongly enough, DPIs are not an option for you.

The last two medication delivery devices are relatively rare for asthmatics. They are infusion pumps and auto-injectors. Infusion pumps for asthma are only used by those with very severe asthma, who need a constant supply of bronchodialator drug (often salbutamol or terbutaline) in their blood system. Often, they use subdermal infusion pumps similar to those used by people with diabetes. I’ve never been severe enough to need one, so I don’t know what they’re like, but they come with many of the same hazards of an insulin infusion pump, and hygiene is very important to avoid infection. Auto-injectors are used by those asthmatics who are prone to status asthmaticus and anaphylaxis. These auto-injectors are exactly the same as those used to treat severe allergic reaction and use the exact same drug (epinephrine) because in many cases, severe asthma attacks are severe allergic reactions. Information on how to use these auto-injectors properly is available from any manufacturer or first aid course.

That’s pretty much it for medication delivery devices for asthma. I haven’t covered any of the out-of-date and obsolete forms of asthma medication delivery devices, though I might examine that history in a later post. In my next post of this series, I’ll talk about home testing devices.

*As an aside, a lot of MDIs contain ethanol as a stabilizer, and this has been known to cause false positives on breathalyzer tests when the breathalyzer is performed shortly after taking your inhaler.

The previous post in this series is here.
The next post in this series is here.

Asthma Treatment 4: Maitnenance meds

So, yesterday, I talked about what asthma control is.

Today, and for the next two posts, I’m going to write about how you get and maintain asthma control. There are three pillars to getting good asthma control: Medicine, exercise, and trigger management. Today, I’m going to talk about medicine.

Most people with asthma need at least one maintenance medicine. Only the mildest of asthmatics can maintain control with just a rescue puffer. Maintenance or preventer meds are taken every day, usually twice a day, to help control asthma. There are several main classes of maintenance asthma medicines:

  • Inhaled corticosteroids
  • Inhaled non-steroidal anti-inflammatories
  • Long-acting bronchodialators
  • Leukotriene receptor antagonists
  • Methylxanthines
  • Antihistamines
  • Oral corticosteroids
  • Humanized antibodies

Inhaled corticosteroids (abbreviated in papers as ICS) are finely-ground anti-inflammatory steroid that you inhale. They work by reducing the inflammation of your airways, making them less swollen and twitchy. They’re the single most common type of asthma maintenance med, and most people who are on other maintenance meds will be on one or more ICS drugs as well. They’re typically delivered either through a dry powder inhaler or through a metered dose inhaler. Sometimes, they’re delivered through a nebulizer. There are too many ICS drugs to list, but a list of common drugs in this class may be found here.

Inhaled non-steroidal anti-inflammatory drugs are an older class of asthma medicine, still used in those with steroid-resistant asthma or those who have a history of bad reactions to inhaled corticosteroids. They work by stabilizing mast cells and preventing the allergic reaction that leads to swelling, inflammation, and twitchy airways. There are two drugs in this class: cromolyn sodium and necromil sodium. They’re not used very often anymore because they’re inconvenient (you need to take them four times a day) and are held to be less safe than ICS and leukotriene receptor antagonists. Since MDIs stopped being produced in 2010 when the CFC propellant was banned, they can only be delivered through a nebulizer. This class has mostly been replaced by the leukotriene receptor antagonists discussed below.

Long-acting bronchodialators¬†(abbreviated LABAs) are a class of drugs that works by binding to a receptor on the outside of the cell, which causes relaxation of the smooth muscle. In this way, they work exactly like asthma rescue medicines, but they last longer. This longer lasting action comes at a price: they usually aren’t fast acting, and so with one exception (formoterol), they can’t be used as asthma rescue medicines. They stop, reverse, and prevent bronchospasms. These medicines are not without risk: The benefit of LABAs to quality of life and asthma control must be weighed against a small but significantly increased risk of sudden, severe and life threatening asthma attacks. This increased risk is either greatly reduced or eliminated entirely (literature is contradictory on this point) in people who are taking inhaled corticosteroids, and therefore these medications are contraindicated in asthma patients who are not taking ICS therapy. What that means is that if you are asthmatic and your doctor has you on a LABA without an ICS, you should talk with your doctor about whether it’s a good idea.

Leukotriene receptor antagonists (abbreviated LRTAs) are a class of drugs that work by inhibiting the action of leukotrienes. In short, they stop allergic reactions before they begin. Common drugs in this class are montekulast, zafirlukast, and zileuton. LRTAs come with a warning for possible neuropsychiatric side effects, the effects of which can be delayed by several years. As such, LRTAs, like LABAs, are a class of drug that is approached with caution and only when a risk-benefit analysis indicates that the potential benefit outweighs the potential risk.

Methylxanthines (also called theophyllines) are a class of drug that is related to caffeine. They are stimulants, anti-inflammatories, and bronchodialators. They work by relaxing the airways and possibly by reducing the inflammation that causes asthma symptoms. There is also some evidence that theophylline might reverse steroid insensitivity in severe asthmatics. Theophylline has a relatively narrow therapeutic window, and when I was on it as a kid, I had to go for weekly blood tests to make sure it wasn’t building up in my system to toxic levels. Due to their side-effects and potential toxicity, theophyllines are only used in people whose asthma is very severe and uncontrolled. On a completely-unrelated-to-the-medicine note: theophylline syrup tastes absolutely terrible, and I learned to swallow pills at four so I wouldn’t have to take it anymore.

Antihistamines are drugs which prevent allergic reactions by either preventing the production of histamine or preventing the binding of histamine to its receptor. It is a broad class which includes many different sub-families but they all work by preventing the allergic reaction from completing by stopping the action of histamine on cells. This in turn prevents allergic inflammation and bronchospasm. Some people with allergic asthma (me included) have allergy medicines included for some asthma attacks (I’m supposed to take diphenhydramine if I think allergies might be playing a role in my asthma attack). There are far, far, far, far, far too many antihistamines to even try to list all of them, but a partial list of antihistamines may be found here.

Oral corticosteroids are the pill version of inhaled corticosteroids, and work in a similar manner, except throughout your whole body rather than just at your lungs. Due to systemic application, they come with a lot of very nasty side-effects, and the risk of side-effects increases as the length of time you’re on them increases. For this reason, doctors try to avoid treating people with oral steroids, and won’t prescribe them except for serious flares or for those who can’t control their asthma any other way.

Humanized antibodies represent the only class of asthma drug I’ve never been on. The only asthma drug in this class is Omalizumab. There is a not-unsubstantial risk of anaphylaxis associated with humanized antibody treatment, and for this reason, humanized antibody treatment is only prescribed to those with moderate to severe asthma that is unresponsive to steroid treatment. They work by blocking cell receptors that lead to serious allergic reactions, including severe allergic asthma and anaphylaxis. Xolair is also¬†very expensive. Depending on dose, it can cost up to $2,000/mo.

For asthma treatment, doctors usually follow a stepwise approach to treatment: This means that asthma medicine is increased if you’re doing badly and if you’re doing well for more than six months, they will try reducing your medicine to see if you can manage on lower doses. This allows for the fact that asthma can change in severity and may actually get better over time, while allowing doctors to respond if your asthma control is lacking. Canadian Thoracic Society sets the guidelines for asthma treatment in Canada, while equivalent organizations set similar guidelines in other countries.

The previous post in this series is here.
The next post in this series is here.

Asthma Treatment 3: Asthma Control

So, today’s post is late because I had planned to write tomorrow’s post instead, but I couldn’t make it make sense, until I realized that you have to know what asthma control is to understand it. So I’m going to write about asthma control.

Put simply, good asthma control happens when your asthma is managed with medication and lifestyle to a sufficient degree that your asthma has the minimum possible impact on your life.

Bad asthma control happens when your asthma is inadequately managed with medication and lifestyle, such that your asthma has a larger impact on your life than necessary.

For the vast majority of asthmatics (all mild intermittent and mild persistent, and most moderate asthmatics), that means good control according to their country’s asthma control guidelines. In Canada, this means all of the following:

  • No daytime attacks
  • No night-time symptoms
  • Reliever medication use <4x/wk
  • No school or work absenteeism due to asthma
  • Normal lung function tests

For a minority of people with asthma (me among them), textbook asthma control is not possible. In our cases, good control is defined by our doctors.

Improving your asthma control is not only helpful to your quality of life and mental well-being, it’s also important for your personal safety. Poor asthma control is a risk factor for fatal and near fatal asthma. Asthma control is thus a safety issue in addition to a wellbeing issue.

If you have asthma, you might be wondering how to tell if you have poor asthma control? Here’s some signs of poor asthma control:

  • Waking up at night one or more times a week because of asthma
  • Rescue puffer does not work as quickly or as completely as it used to
  • You’re using your puffer more than three times a week
  • Your asthma is stopping you from regular activities, like exercise or housecleaning
  • If you have a peak flow meter, your peak flow is regularly <80% of your personal best
  • You’ve needed oral steroids for an asthma flare twice or more in the past year

If you prefer quiz-format monitoring, there are several quizzes around the internet for checking your asthma control. Sites with asthma control quizzes include WebMD,and the Asthma Society of Canada.

What things help asthma control (maintenance treatments and lifestyle changes) and hinder it (triggers) will be discussed in later posts.

The previous post in this series is here.
The next post in this series is here.